Document Detail

Fibrous histiocytoma: a histological and statistical analysis of 155 cases.
MedLine Citation:
PMID:  215975     Owner:  NLM     Status:  MEDLINE    
Various salient histological features were rated from + to +++ in a semiquantitative evaluation of a series of 155 cases of fibrous histiocytoma. Relations between individual histological features, as well as between histological findings, localisation and size of lesions, and age or sex of the patient were tested statistically. Most impressive was an inverse proportional relationship between cellular and fibrillar densities: highly cellular fibrous histiocytomas chiefly showed little fiber formation. Accordingly, cases with marked fiber formation were distinguished by low cellularity. Based on this statistically significant relation, 3 subtypes could be classified on a scale of increasing fiber formation and decreasing cellular density. The majority of cases showed medium cellularity and fibrillar density, with distinct storiform (spokewheel or "whirlygig") pattern which is compatible with typical storiform histocytoma, including clincally progressive, recurrant FH and/or "dermatofibrosarcoma protuberans". The typical patient was more frequently female than male, 40 years of age with a 0.5 to 1.0 cm size tumor node in the lower extremities located in the corium, often with beginning infiltration of the subcutaneous fat tissue.
P Meister; E Konrad; F Krauss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  162     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1979-03-13     Completed Date:  1979-03-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  361-79     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue
Age Factors
Child, Preschool
Connective Tissue / pathology
Histiocytoma, Benign Fibrous / pathology*
Middle Aged
Sex Factors
Skin Neoplasms / pathology
Reg. No./Substance:

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