| Fibrotic response to angiotensin II is blunted in the kidney, but not in the heart, in insulin-sensitive long-lived transgenic dwarf rats. | |
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MedLine Citation:
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PMID: 17143544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin resistance is a characteristic feature of cardiovascular and renal diseases, and angiotensin II (Ang II) has been suggested to induce insulin resistance. The aims of this study were to elucidate the effect of chronic Ang II infusion on vascular reactivity and organ damage in insulin-sensitive rats. We confirmed the following three points. First, there was no significant difference in pressor response to chronic Ang II infusion (600 ng/kg/min) between insulin-sensitive transgenic rats (Tg) and control rats (C). Second, there was no significant difference in cardiac hypertrophy and fibrosis by chronic Ang II infusion between the two groups. However, third, fibrotic response to chronic Ang II infusion evaluated by histopathological scoring in the kidney was significantly decreased in insulin-sensitive transgenic rats (renal fibrosis and nephropathy score: C+Ang II vs Tg+Ang II; 2.5 vs 1.3; p<0.05). Furthermore, the expression of TGF-beta, a fibrosis indicator, was also significantly suppressed in the kidneys of the transgenic rats (TGF-beta1/GAPDH ratio: C+Ang II vs Tg+Ang II; 1.15 vs 0.81; p<0.05). This result indicates that the growth hormone/insulin-like growth factor-1 axis is critically involved in the development of renal injury and fibrosis, rather than hypertension, cardiac hypertrophy, and cardiac fibrosis induced by chronic Ang II administration. |
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Authors:
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Osami Sato; Naoto Ashizawa; Akira Ohtsuru; Ryo Imanishi; Hiroaki Kawano; Shinji Seto; Shunichi Yamashita; Isao Shimokawa; Katsusuke Yano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of molecular medicine Volume: 19 ISSN: 1107-3756 ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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administration & dosage* Animals Animals, Genetically Modified Body Weight / drug effects Dwarfism Echocardiography Fibrosis / etiology*, metabolism Heart Rate / drug effects Infusions, Intravenous Insulin / pharmacology Insulin-Like Growth Factor I / analysis Kidney / drug effects, metabolism, pathology* Male Myocardium / pathology* Organ Specificity RNA, Messenger / metabolism Rats Rats, Wistar Transforming Growth Factor beta1 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Transforming Growth Factor beta1; 11061-68-0/Insulin; 11128-99-7/Angiotensin II; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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