Document Detail


Fibrosis of pulmonary vascular remodeling in carotid artery-jugular vein shunt pulmonary artery hypertension model of rats.
MedLine Citation:
PMID:  21893417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of the present study was to observe the changes of hemodynamics, stereology in pulmonary vascular remodeling and messenger RNA (mRNA) expressions of transforming growth factor beta 1, and receptors in carotid artery-jugular vein (CA-JV) shunt pulmonary artery hypertension model of rats.
METHODS: Thirty-six Sprague-Dawley rats were randomized into three groups: CA-JV group, monocrotaline (MCT) administration group, and control group. Left CA-JV shunts were established in CA-JV group. Dorsal subcutaneous injections of MCT (60 mg kg(-1)) were received in MCT group. Ligations of left common carotid artery and external jugular vein were performed in control group. Right ventricular systolic pressure (RVSP) measurement, histological evaluation of the pulmonary tissue, and mRNA levels of transforming growth factor beta 1 (TGFß1), receptor 1 and receptor 2, were investigated after 6 weeks on MCT group, and after 12 weeks on both control and CA-JV groups.
RESULTS: Compared with control group, RVSP, percentage of fibrous tissue (F%) in pulmonary arterioles, mRNA levels of TGFß1, and receptors of CA-JVand MCT groups increased significantly. Severe hemodynamics change was found in MCT groups. On the other hand, CA-JV group demonstrated more obvious fibrogenesis and TGFß1 signals' upregulation in two pulmonary artery hypertension (PAH) models.
CONCLUSIONS: CA-JV shunt model of rats was a well-established PAH animal model simulating congenital heart disease with systemic-pulmonary shunt.
Authors:
Mai Xiong; Jian-Ping Yao; Zhong-Kai Wu; Bing Liao; Ying-Jie Liang; Xi Zhang; Zhi-Ping Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  41     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-01     Completed Date:  2012-05-01     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  162-6     Citation Subset:  IM    
Affiliation:
Department of Cardiac Surgery, the 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterioles / pathology
Arteriovenous Shunt, Surgical / methods
Carotid Artery, Common / surgery
Disease Models, Animal*
Fibrosis
Gene Expression Regulation / physiology
Hemodynamics / physiology
Hypertension, Pulmonary / etiology*,  metabolism,  pathology,  physiopathology
Jugular Veins / surgery
Male
Pulmonary Artery / pathology*
RNA, Messenger / genetics
Rats
Rats, Sprague-Dawley
Receptors, Transforming Growth Factor beta / biosynthesis,  genetics
Transforming Growth Factor beta1 / biosynthesis,  genetics
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Transforming Growth Factor beta; 0/Transforming Growth Factor beta1
Comments/Corrections

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