| Fibrosis of the human heart and systemic organs in adrenal adenoma. | |
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MedLine Citation:
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PMID: 1345047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In experimental animals, chronic mineralocorticoid (MC) excess is associated with fibrosis of the myocardium and systemic organs, where both a reactive, i.e. interstitial and perivascular, and reparative, i.e. microscopic scarring following cardiac myocyte necrosis, fibrosis are found. We sought to determine if a similar fibrous tissue response was present in human myocardium and systemic organs in association with adrenal adenoma. Postmortem specimens of heart, adrenals, pancreas, lungs, kidney and liver were obtained from 5 patients (age 67 +/- 5 years) with autopsy-proven adrenal adenoma. Documented histologically normal tissue from age-matched patients was used for comparison. Tissue sections were stained with the collagen specific stain Sirius Red F3BA and analyzed using normal and polarized light. Reactive and/or reparative fibrosis was found in the heart, pancreas, adrenal glands and lungs, but not in the kidney or liver. These observations support a link between chronic MC excess and fibrosis of the heart and systemic organs in humans with adrenal adenoma. |
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Authors:
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S E Campbell; A A Diaz-Arias; K T Weber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood pressure Volume: 1 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1994-06-23 Completed Date: 1994-06-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
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Languages: eng Pagination: 149-56 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Missouri-Columbia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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pathology* Adrenal Gland Neoplasms / pathology* Adrenal Glands / pathology Aged Endomyocardial Fibrosis / pathology* Female Fibrosis Humans Lung / pathology Male Middle Aged Myocardium / pathology Pancreas / pathology |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL-31701/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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