Document Detail


Fibrosis and Cardiac Arrhythmias.
MedLine Citation:
PMID:  21150449     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this review article about fibrosis and arrhythmias we show that the amount of collagen, a normal element of the heart muscle, increases with age and in heart disease. The relation between fibrosis and electrophysiological parameters such as conduction, fractionation of electrograms, abnormal impulse initiation as well as arrhythmogenicity is discussed. Next to the amount of fibrosis, we offer data suggesting that collagen texture too plays a role in conduction slowing and arrhythmia vulnerability. Data are shown revealing that fibrosis can also be induced by reduced sodium channel and connexin43 expression. Finally contrast enhanced magnetic resonance to detect fibrosis and VT vulnerability in a non-invasive way, as well as a reduction of fibrosis and arrhythmogenicity by inhibition of the rennin-angiotensin-aldosteron-system, are discussed.
Authors:
Sanne de Jong; Toon Ab van Veen; Harold Vm van Rijen; Jacques Mt de Bakker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-04
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Department of Medical Physiology1, University Medical Center, Utrecht, The Netherlands, the Department of Experimental Cardiology2, Heart failure Research Center, Amsterdam, The Netherlands and the Interuniversity Cardiology Institute of the Netherlands3, Utrecht, The Netherlands.
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