Document Detail

Fibrosing colonopathy in an adult cystic fibrosis patient after discontinuing pancreatic enzyme therapy.
MedLine Citation:
PMID:  15455984     Owner:  NLM     Status:  MEDLINE    
Fibrosing colonopathy, a complication of cystic fibrosis, has generally been reported in young children with exposure to high doses of pancreatic enzymes. The authors report the case of a 25-year-old male with cystic fibrosis who presented with gradually progressive symptoms of bowel obstruction. Pathologic examination of the right colon revealed findings consistent with fibrosing colonopathy. This case is distinctive because of the adult presentation, and because the patient's symptoms developed long after he had discontinued taking a high-strength enzyme preparation. This case suggests that multiple etiologic factors, and not simply exposure to pancreatic enzymes, may result in fibrosing colonopathy in adults with cystic fibrosis.
Elizabeth H Mack; Allan S Brett; Daniel Brown
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  97     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-30     Completed Date:  2004-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  901-4     Citation Subset:  AIM; IM    
Department of Pediatrics, University of South Carolina School of Medicine, Columbia, SC 29203, USA.
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MeSH Terms
Colonic Diseases / complications,  pathology*,  surgery
Cystic Fibrosis / complications*
Gastrointestinal Agents / administration & dosage
Pancrelipase / administration & dosage
Treatment Refusal*
Reg. No./Substance:
0/Gastrointestinal Agents; 53608-75-6/Pancrelipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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