| Fibrosing alveolitis in an infant. | |
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MedLine Citation:
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PMID: 1572449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A three month old female infant presented with unproductive cough, diffuse bilateral fine crackles, tachypnoea and failure to thrive despite a four month therapy with beta 2-agonists and antibiotics. A chest radiograph showing bilateral periphilar infiltrates and a patchy infiltrate in the right upper lobe and lingula did not explain the physical examination with diffuse bilateral fine crackles. As the condition did not improve and arterial oxygen tension (PaO2) and oxygen saturation decreased during the following two months, an open lung biopsy was performed. The surgeon described the lungs as rubbery in consistency and histological findings showed patchy mild interstitial fibrosis and thickened alveolar septa. A therapy with prednisone daily was started and given over a period of four months, but did not show sufficient improvement. Only after addition of azathioprine was clinical improvement and normalization of blood gases noted. |
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Authors:
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J Riedler; A Golser; I Huttegger |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The European respiratory journal Volume: 5 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-06-01 Completed Date: 1992-06-01 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 359-61 Citation Subset: IM |
Affiliation:
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Dept of Paediatric Pulmonology, Kinderspital der Landeskrankenanstalten, Salzburg, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
/
diagnosis,
etiology Azathioprine / administration & dosage Drug Therapy, Combination Female Humans Infant Lung / pathology, radiography Oxygen / blood Prednisone / administration & dosage Pulmonary Fibrosis / blood, diagnosis*, drug therapy |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine; 53-03-2/Prednisone; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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