Document Detail

Fibronectin plasma levels after cadaver kidney transplantation.
MedLine Citation:
PMID:  2981594     Owner:  NLM     Status:  MEDLINE    
The fibronectin plasma levels of 17 patients undergoing cadaver kidney transplantation were determined serially in the postoperative course using laser nephelometry. While 9 patients retained their grafts (group A), the grafts of 8 patients had to be removed (group B), mainly due to rejection, 3 patients had severe infections. In both groups a significant drop of the plasma fibronectin occurred after surgery. There were no significant differences between the two groups in the mean fibronectin levels. After the initial drop the group A patients exhibited rising values leading to a stable level. Progressively declining fibronectin plasma concentrations were found in 2 of 3 severely infected patients. Fluctuating values were found in 3 group B patients without a clear correlation to the rejection crises or the kidney function. The data suggest that the fibronectin plasma level does not seem to be a prognostic marker for graft rejection. But it might be useful in the important and often difficult differentiation between rejection and infection.
R Seitz; M Lutz; R Michalik; H Lange; H G Klingemann; R Egbring
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blut     Volume:  50     ISSN:  0006-5242     ISO Abbreviation:  Blut     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-08     Completed Date:  1985-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173401     Medline TA:  Blut     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  35-43     Citation Subset:  IM    
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MeSH Terms
Creatinine / blood
Cyclosporins / therapeutic use
Cytomegalovirus Infections / etiology
Fibronectins / blood*
Graft Rejection
Immunosuppression / adverse effects
Kidney Transplantation*
Middle Aged
Sepsis / etiology
Shock, Hemorrhagic / etiology
Staphylococcal Infections / etiology
Reg. No./Substance:
0/Cyclosporins; 0/Fibronectins; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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