Document Detail


Fibronectin is a marker for organ involvement and may reflect the severity of preeclampsia.
MedLine Citation:
PMID:  12044316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We have studied whether plasma fibronectin is related to a rise in blood pressure during normal pregnancy, whether it can be used for the early prediction of preeclampsia, and whether plasma fibronectin is a marker for organ involvement in preeclampsia. STUDY DESIGN: Two hundred twenty-eight healthy pregnant nullipara women were examined prospectively during pregnancy. Analyses of fibronectin in plasma were performed in pregnancy weeks 16, 24, 28, 32, and 36. During the same period, 177 patients with suspected preeclampsia and/or intrauterine growth retardation (IUGR) were tested for plasma fibronectin, mainly in the third trimester. RESULTS: In the normal population of pregnant women (n=222/228), fibronectin levels were 0.35 +/- 0.06 g/L in pregnancy week 16 and 0.43 +/- 0.12 g/L in week 36. These levels showed a positive correlation to blood pressure elevation during pregnancy (r=0.21, p=0.006). The six patients in this group (n=6/228) who later developed preeclampsia had higher fibronectin values 0.42 +/- 0.07 g/L already in week 16 (p=0.023). In the population of women with suspected preeclampsia (preeclampsia, n=129; IUGR alone, n=17; hypertension or proteinuria during pregnancy, n=31), fibronectin values were significantly higher, 0.75 +/- 0.27 g/L than in the normal population. Patients with preeclampsia and laboratory signs of organ involvement (n=56) showed significantly higher fibronectin values (0.85 +/- 0.27 g/L) compared to preeclampsia without organ involvement (n=73) [0.76 +/- 0.22 g/L (p=0.03)]. CONCLUSION: Our data show that fibronectin is related to blood pressure in pregnancy. Fibronectin values in women who develop preeclampsia are elevated already in pregnancy week 16 and were higher in those with laboratory signs of organ involvement.
Authors:
E Ostlund; L O Hansson; K Bremme
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy     Volume:  20     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2001  
Date Detail:
Created Date:  2002-06-04     Completed Date:  2002-06-26     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
Affiliation:
Department of Women and Child Health, Division of Obstetrics and Gynaecology, Karolinska Hospital, S-171 76 Stockholm, Sweden. eva.ostlund@ks.se
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers
Female
Fetal Growth Retardation / blood
Fibronectins / blood*
Humans
Pre-Eclampsia / blood*
Pregnancy
Prospective Studies
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fibronectins

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