| Fibronectin and the adhesive properties of rat lymphocytes obtained from different peripheral lymphoid tissues. | |
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MedLine Citation:
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PMID: 2076848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comparative investigation has been carried out on the effect of plasma fibronectin (Fn) on the adhesive properties of normal rat lymphocytes obtained from different lymphoid tissues: blood, spleen, mesenteric and tonsillar lymph nodes. Fn was immobilized on the basis of its ability to bind to gelatin. We established that concentrations of 40-50 micrograms/ml are sufficient for a saturation effect on Fn coating. For spleen cells an adhesion of 55.7 +/- 9.3%, for mesenteric lymph nodes 34.5 +/- 8.7% and for tonsillar cells 33.8 +/- 3.2% was observed. Blood lymphocytes showed the lowest adhesion, 21.3 +/- 4.2%. Compared to the other lymphoid tissues, the spleen cells exhibited a "basal" adherence to surfaces coated with gelatin only: 19.2 +/- 4.1%. T lymphocytes participate to a greater extent in the process, since their number was significantly reduced in cell suspensions after adhesion to both gelatin and gelatin-Fn coated surfaces. The addition of soluble Fn leads to a competitive inhibition of the lymphocyte adhesion to gelatin-Fn coated surfaces. The data demonstrated the important role of Fn for the adhesive interactions of lymphocytes during their functional distribution in the tissues. |
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Authors:
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G Altankov; A Kostadinov; L Marinova |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Haematologia Volume: 23 ISSN: 0017-6559 ISO Abbreviation: Haematologia (Budap) Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-19 Completed Date: 1991-04-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0130266 Medline TA: Haematologia (Budap) Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 151-9 Citation Subset: IM |
Affiliation:
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Central Lab of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion / physiology Collagen / metabolism Fibronectins / isolation & purification, metabolism* Lymph Nodes / physiology Lymphocyte Subsets / physiology Lymphocytes / physiology* Lymphoid Tissue / physiology* Mesentery Palatine Tonsil / physiology Rats Spleen / physiology |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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