Document Detail

Fibromuscular dysplasia of small coronary arteries and fibrosis in the basilar ventricular septum in mitral valve prolapse.
MedLine Citation:
PMID:  9313609     Owner:  NLM     Status:  MEDLINE    
The mechanism of sudden cardiac death in patients with mitral valve prolapse is poorly understood. Twenty-four hearts from patients with mitral valve prolapse who suddenly died (mean age 34 +/- 8 years) and 16 trauma control hearts (mean age 30 +/- 7 years) were histologically studied. Dysplasia of the atrioventricular nodal artery was present in 18 of 24 hearts with mitral valve prolapse and four of 16 controls hearts (p = 0.003). The degree of luminal narrowing, as morphometrically measured, was significantly greater in hearts with mitral valve prolapse (p = 0.003). The degree of fibrosis in the base of the ventricular septum, as calculated by computerized morphometry, was greater in hearts with mitral valve prolapse (p = 0.0002) and independent of age, sex, and heart weight (p = 0.005). We conclude that arterial dysplasia in mitral valve prolapse may contribute to sudden cardiac death mediated by ventricular fibrosis.
A P Burke; A Farb; A Tang; J Smialek; R Virmani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  134     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-91     Citation Subset:  AIM; IM    
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
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MeSH Terms
Case-Control Studies
Coronary Vessels / anatomy & histology,  pathology*
Death, Sudden, Cardiac / etiology,  pathology
Endomyocardial Fibrosis / complications,  pathology*
Fibromuscular Dysplasia / complications*
Heart Septum / anatomy & histology,  pathology*
Heart Ventricles / anatomy & histology,  pathology
Mitral Valve Prolapse / complications*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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