Document Detail


Fibromuscular dysplasia of small coronary arteries and fibrosis in the basilar ventricular septum in mitral valve prolapse.
MedLine Citation:
PMID:  9313609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of sudden cardiac death in patients with mitral valve prolapse is poorly understood. Twenty-four hearts from patients with mitral valve prolapse who suddenly died (mean age 34 +/- 8 years) and 16 trauma control hearts (mean age 30 +/- 7 years) were histologically studied. Dysplasia of the atrioventricular nodal artery was present in 18 of 24 hearts with mitral valve prolapse and four of 16 controls hearts (p = 0.003). The degree of luminal narrowing, as morphometrically measured, was significantly greater in hearts with mitral valve prolapse (p = 0.003). The degree of fibrosis in the base of the ventricular septum, as calculated by computerized morphometry, was greater in hearts with mitral valve prolapse (p = 0.0002) and independent of age, sex, and heart weight (p = 0.005). We conclude that arterial dysplasia in mitral valve prolapse may contribute to sudden cardiac death mediated by ventricular fibrosis.
Authors:
A P Burke; A Farb; A Tang; J Smialek; R Virmani
Related Documents :
10390809 - Anaerobic upflow fixed-film bioreactor for biomethanation of salty cheese whey.
2168469 - Measurement of leukotriene b4 in arterial blood of asthmatic patients during wheezing a...
16783929 - On eulerian constitutive equations for modeling growth and residual stresses in arteries.
18352699 - Dirac neutrino masses from generalized supersymmetry breaking.
3690139 - Joint mobility and mitral valve prolapse in an arab population.
17371389 - Topography of arterial circle of the brain in egyptian spiny mouse (acomys cahirinus, d...
6824409 - Surgical results of anomalous left coronary artery.
1828279 - The surgical treatment of a thoracoabdominal aortic aneurysm with total preservation of...
8652219 - Aortic aneurysm complicating bacterial endocarditis in childhood.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  134     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Coronary Vessels / anatomy & histology,  pathology*
Death, Sudden, Cardiac / etiology,  pathology
Endomyocardial Fibrosis / complications,  pathology*
Female
Fibromuscular Dysplasia / complications*
Heart Septum / anatomy & histology,  pathology*
Heart Ventricles / anatomy & histology,  pathology
Humans
Male
Mitral Valve Prolapse / complications*,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Short- and long-term outcome of narrowed saphenous vein bypass graft: a comparison of Palmaz-Schatz ...
Next Document:  Cardiac abnormalities and cytosine-thymine-guanine trinucleotide repeats in myotonic dystrophy.