Document Detail


Fibromuscular dysplasia of the renal artery responsible for renovascular hypertension: a histological presentation based on a series of 102 patients.
MedLine Citation:
PMID:  15061042     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fibromuscular dysplasia (FMD) is a rare non-atherosclerotic and non-inflammatory disease in the arterial system. The purpose of the study was a retrospective analysis of FMD in the renal artery.
PATIENTS AND METHODS: A total number of 102 patients (mean age: 36.9 years) who suffered from renovascular hypertension underwent a surgical therapy. The operative specimens of the renal arteries were analysed with the lightmicroscop using histological and immunohistochemical methods.
RESULTS: 101 patients (99.02%) presented a medial FMD (extensive-medial subtype in 56 patients, 54.9%, subadventitial subtype in 29 patients, 28.4% and combined subtype in 16 patients, 15.7%). In 1 patient (0.98%) an adventitial FMD was found. We observed the following complications: true and dissecting aneurysms (75 patients, 74.5%), arterio-venous fistulae (2 patients, 1.96%) and chronic thrombosis (10 patients, 9.8%).
CONCLUSIONS: With the progress in angioplasty, not all patients suffering from FMD undergo a primary surgical therapy and therefore this lesion is less seen in the daily work of the histopathologist.
Authors:
P N Vuong; P Desoutter; V Mickley; B Bültmann; K Rothenberger-Janzen; H Guyot; J Janzen
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  33     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-08-26     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM    
Affiliation:
Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Desmin / analysis
Female
Fibromuscular Dysplasia / pathology*,  surgery
Humans
Hypertension, Renal / pathology*,  surgery
Kidney Cortex / blood supply,  pathology
Middle Aged
Muscle Cells / pathology
Nephrectomy
Renal Artery / pathology,  surgery
Renal Artery Obstruction / pathology*,  surgery
Chemical
Reg. No./Substance:
0/Desmin

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