Document Detail

Fibromuscular cap composition is important for the stability of established atherosclerotic plaques in mature WHHL rabbits treated with statins.
MedLine Citation:
PMID:  11427206     Owner:  NLM     Status:  MEDLINE    
We examined the relationship between plaque vulnerability and fibromuscular cap composition using hydrophilic pravastatin and lipophilic fluvastatin. WHHL rabbits aged 10 months were given pravastatin (50 mg/kg) or fluvastatin (20 mg/kg) for 52 weeks. The atherosclerotic lesions were immunohistochemically or conventionally stained and the components were analyzed with a color image analyzer. Compared with the control group, the plasma cholesterol levels were decreased by about 25% in both statin groups. Pravastatin decreased the lipid components (macrophages+extracellular lipids) in whole aortic plaques by 34% and the fibrous caps of coronary plaques by 55%. Fluvastatin decreased the fibromuscular components (smooth muscle cells+collagen fibers) in whole aortic plaques and in the fibromuscular caps of the aortic and coronary plaques. In the pravastatin group, the vulnerability index, the ratio of (lipid components)/(fibromuscular components), was decreased in whole aortic plaques by 28% and in the fibromuscular caps of coronary lesions by 61%, while the indexes were increased in the fluvastatin group. The incidence of vulnerable plaques was decreased by 74% in the coronary plaques of the pravastatin group. Our results suggest that the stability of atheromatous plaques was improved due to a decrease of the lipid components and vulnerability index of the fibromuscular cap by pravastatin.
M Shiomi; T Ito; Y Hirouchi; M Enomoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  157     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-27     Completed Date:  2001-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Institute for Experimental Animals, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
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MeSH Terms
Anticholesteremic Agents / pharmacology*
Arteriosclerosis / etiology,  pathology*,  prevention & control
Fatty Acids, Monounsaturated / pharmacology*,  therapeutic use
Indoles / pharmacology*,  therapeutic use
Muscle, Smooth, Vascular / pathology
Pravastatin / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Fatty Acids, Monounsaturated; 0/Indoles; 81093-37-0/Pravastatin; 93957-54-1/fluvastatin

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