Document Detail


Fibromatosis of the Cervical Region Following Laminectomy: A Case Report and Literature Review.
MedLine Citation:
PMID:  21912314     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
STRUCTURED ABSTRACT AND KEY WORDS: Study Design. A case report and a discussion of recent published data.Objective. To highlight the occurrence of post-operative fibromatosis arising in the cervical spine.Summary of Background Data. Fibromatosis is a benign, locally invasive fibroblastic proliferation that can cause compressive effects on adjacent structures. Although the precise etiology of fibromatosis remains unclear, numerous studies have investigated the role of pluripotent mesenchymal stem cells in beta-catenin regulated tumorigenesis. At present, aggressive fibromatosis is managed with wide local excision. Postoperative radiation therapy is indicated for incomplete excision.Methods. A 48-year-old woman presented with a two-year history of enlarging paracervical fibromatosis after undergoing extensive cervicothoracic instrumentation for excision of an extradural schwannoma. The patient underwent wide local excision of the neck mass with right trapezius myocutaneous flap reconstruction of the subsequent defect.Results. Histologically, the lesion was shown to be fibromatosis. Six months post-operatively the patient is doing well with no recurrence.Conclusion. Fibromatosis is an important diagnosis to consider when evaluating locally aggressive spinal lesions at sites of prior operative repair. Molecular and genetic studies pertaining to the role of mesenchymal stem cells and beta-catenin in the pathogenesis of aggressive fibromatosis tumors could lead to possible worthwhile treatment strategies in the future.
Authors:
Shruti Sevak; Andrew L Blount; Sandra Cottingham; Mark Delano; Douglas L Vander Woude; John Stevenson; Mathew H Chung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-8
Journal Detail:
Title:  Spine     Volume:  -     ISSN:  1528-1159     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Michigan State University College of Human Medicine, Grand Rapids, Michigan 2Grand Rapids Medical Education Partners, Michigan State University, General Surgery Residency, Plastic Surgery Residency, Grand Rapids, Michigan 3Spectrum Health Hospitals, Department of Pathology, Grand Rapids, Michigan 4Advanced Radiology Services, PC, Division of Radiology and Biomedical Imaging, Grand Rapids, Michigan 5 Division of Plastic Surgery, Michigan State College of Human Medicine, Grand Rapids, Michigan 6Great Lakes Neurological Associates, PC, Grand Rapids, Michigan 7Spectrum Health Medical Group, Grand Rapids, Michigan.
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