Document Detail


Fibrolamellar hepatocellular carcinoma in an infant and literature review.
MedLine Citation:
PMID:  19131794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatocellular carcinoma (HCC) is a rare pediatric neoplasm exceptionally reported in infants and fibrolamellar hepatocarcinoma (FLC) a HCC variant. Controversy exists whether FLC has a better prognosis than classic HCC, although recent studies of children and young adults with FLC did not report a better outcome. We present a 4-month-old male infant without any related metabolic or infectious disease who developed a metastatic and multifocal FLC. Serum alpha-fetoprotein determinations were always normal. Induction chemotherapy using cisplatin and Adriamycin resulted in a partial response, however, refractory disease developed and regional metastasis precluded surgical resection. The child died from tumoral progression.
Authors:
Ofelia Cruz; Astrid Laguna; Margarita Vancells; Lucas Krauel; Marilyn Medina; Jaume Mora
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  30     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-02-03     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-71     Citation Subset:  IM    
Affiliation:
Department of Oncology, Hospital San Joan de Déu, Universidad de Barcelona, Spain. ocruz@hsjdbcn.org
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Hepatocellular / drug therapy,  metabolism,  pathology*
Chemotherapy, Adjuvant
Cisplatin / administration & dosage
Doxorubicin / administration & dosage
Fatal Outcome
Humans
Infant
Liver Neoplasms / drug therapy,  metabolism,  pathology*
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local / diagnosis,  drug therapy
Prognosis
Tomography, X-Ray Computed
Treatment Outcome
alpha-Fetoproteins / metabolism
Chemical
Reg. No./Substance:
0/alpha-Fetoproteins; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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