| Fibrolamellar hepatocellular carcinoma in an infant and literature review. | |
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MedLine Citation:
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PMID: 19131794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocellular carcinoma (HCC) is a rare pediatric neoplasm exceptionally reported in infants and fibrolamellar hepatocarcinoma (FLC) a HCC variant. Controversy exists whether FLC has a better prognosis than classic HCC, although recent studies of children and young adults with FLC did not report a better outcome. We present a 4-month-old male infant without any related metabolic or infectious disease who developed a metastatic and multifocal FLC. Serum alpha-fetoprotein determinations were always normal. Induction chemotherapy using cisplatin and Adriamycin resulted in a partial response, however, refractory disease developed and regional metastasis precluded surgical resection. The child died from tumoral progression. |
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Authors:
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Ofelia Cruz; Astrid Laguna; Margarita Vancells; Lucas Krauel; Marilyn Medina; Jaume Mora |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 30 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-09 Completed Date: 2009-02-03 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 968-71 Citation Subset: IM |
Affiliation:
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Department of Oncology, Hospital San Joan de Déu, Universidad de Barcelona, Spain. ocruz@hsjdbcn.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use* Carcinoma, Hepatocellular / drug therapy, metabolism, pathology* Chemotherapy, Adjuvant Cisplatin / administration & dosage Doxorubicin / administration & dosage Fatal Outcome Humans Infant Liver Neoplasms / drug therapy, metabolism, pathology* Magnetic Resonance Imaging Male Neoplasm Recurrence, Local / diagnosis, drug therapy Prognosis Tomography, X-Ray Computed Treatment Outcome alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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