| Fibrogenesis in nonalcoholic steatohepatitis. | |
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MedLine Citation:
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PMID: 21476913 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nonalcoholic steatohepatitis includes a wide spectrum of liver injury, ranging from simple inflammation to fibrosis and cirrhosis. Whereas simple steatosis has a benign clinical course, steatohepatitis is a recognized cause of progressive liver fibrosis and can develop, in some circumstances, into cirrhosis. The main cause of fibrogenesis is represented by the activation of myofibroblastic cells, which then start to produce matrix filaments. Matrix-producing cells, although mainly constituted of hepatic stellate cells, may have a different origin in the liver. This article will provide information on the sources of matrix-producing cells and the mechanisms involved in the development of fibrogenesis, with particular attention paid to the pathophysiological implications leading from steatohepatitis to fibrosis and cirrhosis. |
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Authors:
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Samuele De Minicis; Gianluca Svegliati-Baroni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of gastroenterology & hepatology Volume: 5 ISSN: 1747-4132 ISO Abbreviation: Expert Rev Gastroenterol Hepatol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278199 Medline TA: Expert Rev Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 179-87 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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