Document Detail

Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature.
MedLine Citation:
PMID:  19608080     Owner:  NLM     Status:  MEDLINE    
Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor. One lesion had up to 4 mitotic figures per 10 high-power fields, including rare atypical mitotic figures. The remaining 3 cases lacked mitotic activity. Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence. The fourth case was lost to follow-up. It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance. The clinicopathologic features of each case are discussed, and a review of the literature is provided.
Lei Huo; Michael Z Gilcrease
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-05-23
Journal Detail:
Title:  Annals of diagnostic pathology     Volume:  13     ISSN:  1532-8198     ISO Abbreviation:  Ann Diagn Pathol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-17     Completed Date:  2009-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800503     Medline TA:  Ann Diagn Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
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MeSH Terms
Breast Neoplasms / diagnosis,  pathology*
Diagnosis, Differential
Fibroadenoma / diagnosis,  pathology
Middle Aged
Neoplasms, Fibroepithelial / diagnosis,  pathology*
Phyllodes Tumor / diagnosis,  pathology
Stromal Cells / pathology*

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