| Fibroepithelial lesions of the breast with pleomorphic stromal giant cells: a clinicopathologic study of 4 cases and review of the literature. | |
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MedLine Citation:
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PMID: 19608080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pleomorphic stromal giant cells are occasionally found as an incidental finding in breast tissue but are only rarely seen in fibroepithelial lesions. In this report, we describe 4 fibroadenoma-like lesions of the breast with pleomorphic stromal giant cells. Two cases had focal stromal hypercellularity, one of which was with architectural features borderline between a fibroadenoma and a phyllodes tumor, but none was considered diagnostic of phyllodes tumor. One lesion had up to 4 mitotic figures per 10 high-power fields, including rare atypical mitotic figures. The remaining 3 cases lacked mitotic activity. Follow-up for 3 cases at 16 to 59 months revealed no evidence of tumor recurrence. The fourth case was lost to follow-up. It appears that the presence of pleomorphic stromal giant cells in an otherwise benign fibroepithelial lesion has no adverse clinical significance. The clinicopathologic features of each case are discussed, and a review of the literature is provided. |
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Authors:
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Lei Huo; Michael Z Gilcrease |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-05-23 |
Journal Detail:
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Title: Annals of diagnostic pathology Volume: 13 ISSN: 1532-8198 ISO Abbreviation: Ann Diagn Pathol Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-17 Completed Date: 2009-10-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800503 Medline TA: Ann Diagn Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 226-32 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. leihuo@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Neoplasms / diagnosis, pathology* Diagnosis, Differential Female Fibroadenoma / diagnosis, pathology Humans Middle Aged Mitosis Neoplasms, Fibroepithelial / diagnosis, pathology* Phyllodes Tumor / diagnosis, pathology Stromal Cells / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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