| Fibroblast mitogenic activity of lung lavage fluid from infants with chronic lung disease of prematurity. | |
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MedLine Citation:
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PMID: 11978752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Lung fibrosis is thought to be important in chronic lung disease of prematurity (CLD). METHODS: Fibroblast proliferative activity was assessed in 207 bronchoalveolar lavage fluid (BALF) samples from 43 infants. Sixteen developed CLD (birth weight 765 g (630-1230), gestation 26.5 weeks (23-29)), 18 developed respiratory distress syndrome (RDS) (birth weight 1415 g (430-4160), gestation 31 weeks (23-39)), and nine control infants (birth weight 2110 g (900-3720), gestation 32 weeks (26-41)) received mechanical ventilation for non-pulmonary reasons. RESULTS: The fibroblast proliferative activity relative to 10% fetal calf serum was 64-75% in infants with CLD, 55-86% in the RDS group, and 42-68% in control infants during the first 5 weeks of life. Only at day 3 was there a difference between the groups (CLD 72% v control 42%, p < 0.01; RDS 63% v control 42%, p < 0.05). With the use of neutralising antibodies, platelet derived growth factor BB (PDGF-BB) and epidermal growth factor were undetectable, and insulin-like growth factor I (IGF-I) accounted for 14% (p < 0.05) and 11% (p < 0.005) of BALF mitogenic activity from the RDS and CLD groups respectively. CONCLUSIONS: The mitogenic activity of BALF was similar in the three groups studied and was only partially accounted for by IGF-I. Growth factors other than PDGF-BB and IGF-I contribute significantly to this process. |
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Authors:
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A E Currie; M Kelly; J R Vyas; H Pandya; D Field; S Kotecha |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 86 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-29 Completed Date: 2002-07-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
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Languages: eng Pagination: F193-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Child Health, University of Leicester, Leicester LE2 7LX, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchoalveolar Lavage Fluid
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cytology* Cells, Cultured Chronic Disease Female Fibroblasts / pathology* Gestational Age Humans Infant Infant, Newborn Infant, Premature, Diseases / pathology*, therapy Insulin-Like Growth Factor I / physiology Male Proto-Oncogene Proteins c-sis / physiology Pulmonary Fibrosis / pathology*, therapy Pulmonary Surfactants / therapeutic use Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-sis; 0/Pulmonary Surfactants; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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