Document Detail

Fibroblast mitogenic activity of lung lavage fluid from infants with chronic lung disease of prematurity.
MedLine Citation:
PMID:  11978752     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lung fibrosis is thought to be important in chronic lung disease of prematurity (CLD). METHODS: Fibroblast proliferative activity was assessed in 207 bronchoalveolar lavage fluid (BALF) samples from 43 infants. Sixteen developed CLD (birth weight 765 g (630-1230), gestation 26.5 weeks (23-29)), 18 developed respiratory distress syndrome (RDS) (birth weight 1415 g (430-4160), gestation 31 weeks (23-39)), and nine control infants (birth weight 2110 g (900-3720), gestation 32 weeks (26-41)) received mechanical ventilation for non-pulmonary reasons. RESULTS: The fibroblast proliferative activity relative to 10% fetal calf serum was 64-75% in infants with CLD, 55-86% in the RDS group, and 42-68% in control infants during the first 5 weeks of life. Only at day 3 was there a difference between the groups (CLD 72% v control 42%, p < 0.01; RDS 63% v control 42%, p < 0.05). With the use of neutralising antibodies, platelet derived growth factor BB (PDGF-BB) and epidermal growth factor were undetectable, and insulin-like growth factor I (IGF-I) accounted for 14% (p < 0.05) and 11% (p < 0.005) of BALF mitogenic activity from the RDS and CLD groups respectively. CONCLUSIONS: The mitogenic activity of BALF was similar in the three groups studied and was only partially accounted for by IGF-I. Growth factors other than PDGF-BB and IGF-I contribute significantly to this process.
A E Currie; M Kelly; J R Vyas; H Pandya; D Field; S Kotecha
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  86     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-29     Completed Date:  2002-07-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F193-7     Citation Subset:  AIM; IM    
Department of Child Health, University of Leicester, Leicester LE2 7LX, UK.
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MeSH Terms
Bronchoalveolar Lavage Fluid / cytology*
Cells, Cultured
Chronic Disease
Fibroblasts / pathology*
Gestational Age
Infant, Newborn
Infant, Premature, Diseases / pathology*,  therapy
Insulin-Like Growth Factor I / physiology
Proto-Oncogene Proteins c-sis / physiology
Pulmonary Fibrosis / pathology*,  therapy
Pulmonary Surfactants / therapeutic use
Respiration, Artificial
Reg. No./Substance:
0/Proto-Oncogene Proteins c-sis; 0/Pulmonary Surfactants; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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