Document Detail

Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center.
MedLine Citation:
PMID:  18054407     Owner:  NLM     Status:  MEDLINE    
Over the past several years, increasing attention has been focused on understanding signaling pathways that control key events during midgestational heart development. During this period of development, the heart tube transforms into a functioning organ that must maintain its own blood supply and grow and respond to the physiologic needs of the organism. A critical event that occurs during midgestational heart development is the formation of the epicardium, which functions as a source of cells and as a signaling center that regulates myocardial growth and coronary vascular development. This review will describe our understanding of the role and the mechanism by which the epicardium governs these developmental events, primarily as a result of studies in the mouse. We focus on two key growth factor pathways: fibroblast growth factor and Hedgehog signaling.
Kory J Lavine; David M Ornitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-12-03
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  24     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Cell Proliferation
Coronary Vessels / embryology
Fibroblast Growth Factors / metabolism*
Hedgehog Proteins / metabolism*
Myocardium / cytology,  metabolism*
Signal Transduction*
Grant Support
Reg. No./Substance:
0/Hedgehog Proteins; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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