Document Detail

Fibroblast growth factor signaling in cranial suture development and pathogenesis.
MedLine Citation:
PMID:  18391500     Owner:  NLM     Status:  MEDLINE    
Apert, Pfeiffer and Crouzon syndromes are congenital craniosynostosis syndromes caused by mutations that perturb the level of fibroblast growth factor receptor (FGFR) signaling. The cellular and molecular impact of these mutations have been studied in vitro and in animal models in vivo. Here, I highlight the complexity of the FGF/FGFR signaling system and review the candidate modifiers responsible for regulating the levels of FGF/FGFR signaling in tissues. I also review what we have learned from the phenotypic analysis of mice that model these craniosynostosis syndromes and discuss some in vivo strategies for further understanding as well as alleviating the associated craniofacial defects.
Mohammad K Hajihosseini
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Frontiers of oral biology     Volume:  12     ISSN:  1420-2433     ISO Abbreviation:  Front Oral Biol     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812095     Medline TA:  Front Oral Biol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  160-77     Citation Subset:  D; IM    
School of Biological Sciences, University of East Anglia, Norwich, UK.
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MeSH Terms
Cranial Sutures / growth & development*
Craniosynostoses / etiology*
Disease Models, Animal
Fibroblast Growth Factors / genetics,  physiology*
Mutation / genetics
Receptors, Fibroblast Growth Factor / genetics,  physiology
Signal Transduction / genetics,  physiology*
Reg. No./Substance:
0/Receptors, Fibroblast Growth Factor; 62031-54-3/Fibroblast Growth Factors

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