Document Detail


Fibroblast growth factor in the extracellular matrix of dystrophic (mdx) mouse muscle.
MedLine Citation:
PMID:  2717945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polyclonal antibody F547 reacts with a bovine basic fibroblast growth factor (bFGF) and a human recombinant bFGF, but not with bovine acidic fibroblast growth factor. This antibody localized bFGF in the extracellular matrix of mouse skeletal muscle, primarily in the fiber endomysium, which includes the heparin-containing basal lamina. In mdx mouse muscle, which displays persistent regeneration, FGF levels in the extracellular matrix are higher than those in controls. Overabundance of matrix FGF in mdx muscles may be related to an increase in both satellite cell and regenerative activity in the dystrophic muscle and may help explain the benign phenotype of mdx animals compared with the genetically identical human Duchenne muscular dystrophy.
Authors:
J DiMario; N Buffinger; S Yamada; R C Strohman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  244     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  688-90     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Animals
Extracellular Matrix / metabolism*
Fibroblast Growth Factors / metabolism*
Heparin / metabolism
Immunoblotting
Mice
Muscles / physiopathology*
Muscular Dystrophy, Animal / genetics,  physiopathology*
Phenotype
Regeneration
Tissue Distribution
Grant Support
ID/Acronym/Agency:
R01 AG02832/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
62031-54-3/Fibroblast Growth Factors; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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