Document Detail

Fibroblast growth factor 4 gene therapy for chronic ischemic heart disease.
MedLine Citation:
PMID:  18555186     Owner:  NLM     Status:  MEDLINE    
Therapeutic myocardial angiogenesis and arteriogenesis represent a novel treatment strategy for patients with angina refractory to traditional medical and surgical therapies. The fibroblast growth factors are a family of proteins that are known mediators of angio-/arteriogenesis. Based on promising preclinical animal data, a series of four randomized placebo-controlled clinical trials have been conducted to determine the safety and efficacy of local delivery of fibroblast growth factor 4 with the use of adenovirus-vector-mediated gene transfer to induce myocardial angio-/arteriogenesis in patients with stable angina. This review describes the scientific rationale underlying these clinical trials, provides an overview of their results, and discusses the implications for future studies.
Navin K Kapur; Jeffrey J Rade
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  18     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-41     Citation Subset:  IM    
Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Adenoviridae / genetics
Chronic Disease
Clinical Trials as Topic
Collateral Circulation
Coronary Circulation
Fibroblast Growth Factor 4 / genetics,  metabolism*
Gene Therapy / adverse effects,  methods*
Gene Transfer Techniques
Genetic Vectors
Myocardial Ischemia / genetics,  metabolism,  physiopathology,  therapy*
Neovascularization, Physiologic*
Patient Selection
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Fibroblast Growth Factor 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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