| Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels. | |
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MedLine Citation:
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PMID: 22304432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibroblast growth factor-2 (FGF2) protects the heart from ischemia-reperfusion (I-R) injury via a vast network of protein kinases. In the heart, downstream effectors of these FGF2-triggered signals have not yet been identified. It is hypothesized that nitric oxide (NO) signaling and ATP-sensitive potassium (K(ATP)) channel activity are key effectors of protein kinases activated by FGF2-mediated cardioprotection. Hearts with a cardiac-specific overexpression of FGF2 (FGF2 Tg) were subjected to I-R injury in the absence or the presence of selective inhibitors of NO synthase (NOS) isoforms or sarcolemmal (sarcK(ATP)) and mitochondrial (mitoK(ATP)) K(ATP) channels. Multiple NOS isoforms are necessary for FGF2-mediated cardioprotection, and nitrite levels are significantly reduced in FGF2 Tg hearts upon inhibition of protein kinase C or mitogen-activated protein kinases. Likewise, sarcK(ATP) and mitoK(ATP) channels are important for cardioprotection elicited by endogenous FGF2. These findings suggest that FGF2-induced cardioprotection occurs via protein kinase-NOS pathways as well as K(ATP) channel activity. |
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Authors:
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Janet R Manning; Gregory Carpenter; Darius R Porter; Stacey L House; Daniel A Pietras; Thomas Doetschman; Jo el J Schultz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-02-06 |
Journal Detail:
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Title: Growth factors (Chur, Switzerland) Volume: 30 ISSN: 1029-2292 ISO Abbreviation: Growth Factors Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-26 Completed Date: 2012-07-23 Revised Date: 2013-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9000468 Medline TA: Growth Factors Country: England |
Other Details:
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Languages: eng Pagination: 124-39 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Enzyme Activation Fibroblast Growth Factor 2 / metabolism* Humans KATP Channels / metabolism* Mice Myocardial Infarction / metabolism, prevention & control* Nitric Oxide / metabolism* Nitric Oxide Synthase / metabolism Potassium Channels / metabolism Protein Kinases / metabolism* Reperfusion Injury / metabolism Sarcolemma / metabolism Signal Transduction* Up-Regulation* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL075633/HL/NHLBI NIH HHS; T35 DK060444/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/KATP Channels; 0/Potassium Channels; 0/mitochondrial K(ATP) channel; 10102-43-9/Nitric Oxide; 103107-01-3/Fibroblast Growth Factor 2; EC 1.14.13.39/Nitric Oxide Synthase; EC 2.7.-/Protein Kinases |
| Comments/Corrections | |
Erratum In:
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Growth Factors. 2012 Dec;30(6):418 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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