| Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. | |
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MedLine Citation:
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PMID: 23183168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibroblast growth factor-19 (FGF19) and its rodent ortholog, FGF15, are hormones produced in the distal small intestine and secreted into the circulation after a meal. In addition to controlling the enterohepatic circulation of bile acids, FGF15/19 also regulates systemic lipid and glucose metabolism. In these experiments we investigated the hypothesis that, like other gut-derived postprandial hormones, FGF15/19 can act in the central nervous system to elicit its metabolic effects. We found that FGF-receptors 1 and 4 are present in rat hypothalamus, and that their expression was reduced by up to 60% in high-fat fed rats relative to lean controls. Consistent with a potential role for brain FGF15/19 signaling to regulate energy and glucose homeostasis, and with a previous report that intracerebroventricular (i.c.v.) administration of FGF19 increases energy expenditure, we report that acute i.c.v. FGF19 reduces 24-h food intake and body weight, and acutely improves glucose tolerance. Conversely, i.c.v. administration of an FGF-receptor inhibitor increases food intake and impairs glucose tolerance, suggesting a physiological role for brain FGF receptor signaling. Together, these findings identify the central nervous system as a potentially important target for the beneficial effects of FGF19 in the treatment of obesity and diabetes. |
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Authors:
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Karen K Ryan; Rohit Kohli; Ruth Gutierrez-Aguilar; Shrawan G Gaitonde; Stephen C Woods; Randy J Seeley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-11-26 |
Journal Detail:
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Title: Endocrinology Volume: 154 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-25 Completed Date: 2013-02-22 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: AIM; IM |
Affiliation:
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The University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Cincinnati, OH 45237, USA. karen.ryan@uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects* Brain / drug effects*, metabolism* Eating / drug effects* Energy Metabolism / drug effects Fibroblast Growth Factors / pharmacology* Glucose / metabolism* Humans Male Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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DK017844/DK/NIDDK NIH HHS; DK082173/DK/NIDDK NIH HHS; DK084310/DK/NIDDK NIH HHS; DK093848/DK/NIDDK NIH HHS; HL111319/HL/NHLBI NIH HHS; R01 DK093848/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose; 62031-54-3/Fibroblast Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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