| FibroSURE and FibroScan in relation to treatment response in chronic hepatitis C virus. | |
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MedLine Citation:
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PMID: 22147963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus (HCV) cohort. METHODS: Patients with chronic HCV were randomized to receive interferon-based therapy for 24 (genotypes 2/3) or 48 (genotype 1) wk. FibroSURE™ (FS) was assessed at baseline and at week-12 post-treatment follow-up. Baseline biopsy for METAVIR was assessed by a single pathologist. FibroScan(®) transient elastography (TE) was performed during treatment in a patient subset. RESULTS: Two thousand and sixty patients (n = 253 in Asia) were classified as METAVIR F0-1 (n = 1682) or F2-4 (n = 378). For F2-4, FS (n = 2055) had sensitivity and specificity of 0.87 and 0.61, respectively, with area under the receiver-operating curve of 0.82; corresponding values for TE (n = 214) and combined FS/TE (n = 209) were 0.77, 0.88 and 0.88, and 0.93, 0.68 and 0.88. Overall FS/TE agreement for F2-4 was 71% (κ = 0.41) and higher in Asians vs non-Asians (κ = 0.86 vs 0.35; P < 0.001). Combined FS/TE had 97% accuracy in Asians (n = 33). Baseline FS (0.38 vs 0.51, P < 0.001) and TE (8.0 kPa vs 11.9 kPa, P = 0.006) scores were lower in patients with sustained virological response than in nonresponders, and were maintained through follow-up. CONCLUSION: FS and TE may reliably differentiate mild from moderate-advanced disease, with a potential for high diagnostic accuracy in Asians with chronic HCV. |
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Authors:
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Keyur Patel; Mireen Friedrich-Rust; Yoav Lurie; Mircea Grigorescu; Carol Stanciu; Chuan-Mo Lee; Eugene R Schiff; Dieter Häussinger; Michael P Manns; Guido Gerken; Isabelle Colle; Michael Torbenson; Erik Pulkstenis; G Mani Subramanian; John G McHutchison; Stefan Zeuzem |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-07 Completed Date: 2012-02-08 Revised Date: 2013-05-22 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4581-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Duke Clinical Research Institute, Durham, NC 27715, United States. keyur.patel@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use* Asian Continental Ancestry Group Biopsy Cohort Studies Elasticity Imaging Techniques / methods* Female Fibrosis Hepacivirus / genetics, metabolism* Hepatitis C, Chronic / drug therapy*, genetics, pathology*, physiopathology* Humans Interferons / therapeutic use* Liver / pathology Male Middle Aged Prospective Studies ROC Curve |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 9008-11-1/Interferons |
| Comments/Corrections | |
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