Document Detail


Fibrinopeptide A excretion in urine in patients with atherosclerotic artery disease.
MedLine Citation:
PMID:  4024054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Urinary fpA excretion and fpA in plasma were studied in patients with peripheral artery disease, aortic aneurysm, severe coronary artery disease, acute myocardial infarction and in normal controls. Mean urinary fpA was significantly higher in all groups of patients than in normal controls whose excretion was 1.9 +/- 1.2 micrograms/24 hours (mean +/- SD). We found a good correlation between urinary fpA excretion and plasma fpA (r = 0.68, p less than 0.01, n = 81). The highest levels of urinary fpA were found in 9 patients with aortic aneurysm (11.9 +/- 6.1 micrograms/24 hours). The 10 patients with acute myocardial infarction had also abnormally elevated values (4.3 +/- 1.8 micrograms/24 hours) which were only slightly higher than the levels found in another 10 patients with myocardial infarction receiving subcutaneous heparin in a dosage of 2 X 5000 IU daily (2.9 +/- 1.7 micrograms/24 hours). The 13 patients with peripheral artery disease showed an increase in urinary fpA excretion from 4.0 +/- 1.7 to 10.5 +/- 2.3 micrograms/24 hours after percutaneous angioplasty (p less than 0.001). These data demonstrate that urinary fpA excretion may represent a valid means to detect the cumulative effect of thrombin action on fibrinogen in patients with atherosclerotic vascular disease and after therapeutic intervention.
Authors:
A Gallino; A Haeberli; P W Straub
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  39     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-04     Completed Date:  1985-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aortic Aneurysm / urine
Arteriosclerosis / blood,  urine*
Fibrinogen / urine*
Fibrinopeptide A / blood,  urine*
Humans
Myocardial Infarction / urine
Radioimmunoassay
Chemical
Reg. No./Substance:
25422-31-5/Fibrinopeptide A; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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