Document Detail


Fibrinolytic treatment in left ventricular mobile thrombi with low ejection fraction: results and follow-up of seven cases.
MedLine Citation:
PMID:  17492402     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Left ventricular mobile thrombi carry high risk of embolism and need early treatment in which the appropriate treatment is still controversial. Because most patients with mobile thrombi have low ejection fraction and also accompanying heart failure symptoms, decision of surgical treatment is not always easy and thus effective medical treatment is crucial. METHOD: In this paper we present, treatment and follow-up of seven patients with mobile thrombi who underwent fibrinolytic treatment between 2002 and 2006. RESULTS: In four cases, mobile thrombi disappeared completely while echocardiographically regressed to lower size with decreased mobility in the other three patients. On 6th month follow-up, complete lysis of the thrombi in six patients was observed with warfarin treatment. No major complications were seen in the patients. CONCLUSION: In case of mobile left ventricular thrombi with concomitant low ejection fraction and heart failure fibrinolytic treatment might be a therapeutic option.
Authors:
Ibrahim Sari; Vedat Davutoğlu; Serdar Soydinc; Murat Sucu; Orhan Ozer
Publication Detail:
Type:  Journal Article     Date:  2007-05-11
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  25     ISSN:  0929-5305     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, School of Medicine, Gaziantep University, 27310 Gaziantep, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anticoagulants / therapeutic use
Fibrinolytic Agents / therapeutic use*
Heart Diseases / drug therapy*,  physiopathology,  ultrasonography
Humans
Male
Middle Aged
Retrospective Studies
Streptokinase / therapeutic use*
Stroke Volume*
Thrombolytic Therapy*
Thrombosis / drug therapy*,  physiopathology,  ultrasonography
Tissue Plasminogen Activator / therapeutic use*
Treatment Outcome
Ventricular Function, Left*
Warfarin / therapeutic use
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinolytic Agents; 81-81-2/Warfarin; EC 3.4.-/Streptokinase; EC 3.4.21.68/Tissue Plasminogen Activator

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