Document Detail

Fibrinolytic therapy with rt-PA in a patient with paroxysmal nocturnal hemoglobinuria and Budd-Chiari syndrome.
MedLine Citation:
PMID:  12707719     Owner:  NLM     Status:  MEDLINE    
Paroxysmal nocturnal hemoglobinuria (PNH) is associated with a high risk of thrombosis, particularly in the peripheral, cerebral, and abdominal veins. We report a patient with an occlusion of the hepatic veins and a slit shape narrowing of the cava inferior consistent with the Budd-Chiari syndrome in whom intravenous fibrinolytic therapy with recombinant tissue plasminogen activator (rt-PA) was applied. Systemic rt-PA was given in a dose of 25 mg rt-PA over 3 h and 25 mg rt-PA as constant intravenous infusion over the next 21 h leading to an incomplete recanalization. The same protocol was applied again 2 days later, resulting in a complete recanalization of the hepatic veins and the vena cava inferior. Our case shows that exclusive systemic application of rt-PA can result in full anatomic and clinical restoration.
A C Hauser; A Brichta; I Pabinger-Fasching; U Jäger
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2003-04-18
Journal Detail:
Title:  Annals of hematology     Volume:  82     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-09     Completed Date:  2003-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
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MeSH Terms
Body Weight / drug effects
Budd-Chiari Syndrome / drug therapy*,  etiology,  ultrasonography
Hemoglobinuria, Paroxysmal / complications,  drug therapy*
Infusions, Intravenous
Thrombolytic Therapy / methods*
Tissue Plasminogen Activator / administration & dosage*
Treatment Outcome
Reg. No./Substance:
EC Plasminogen Activator

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