Document Detail

Fibrinolytic function and atrial fibrillation.
MedLine Citation:
PMID:  12818244     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia, which is associated with a substantial risk of stroke and thromboembolism. A prothrombotic or hypercoagulable state has been observed in these patients, although previous studies have mainly focused on various clotting factors, endothelial damage or dysfunction markers and platelet activation. However, fibrinolytic function has been less frequently studied, despite the fibrinolytic system playing an important role in preventing intravascular thrombosis. Indeed, increasing evidence suggests that an imbalance between the fibrinolytic function is of great importance in cardiovascular disease. This review will begin by providing a brief approach to fibrinolytic function and examine previous studies about fibrinolytic activity and atrial fibrillation.
Francisco Marín; Vanessa Roldán; Gregory Y H Lip
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Thrombosis research     Volume:  109     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-06-23     Completed Date:  2004-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-40     Citation Subset:  IM    
Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, B18 7QH, Birmingham, England, UK.
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MeSH Terms
Atrial Fibrillation / blood*,  complications
Cardiovascular Diseases / blood
Disease Susceptibility
Fibrinogen / physiology
Fibrinolysis* / drug effects
Fibrinolytic Agents / pharmacology,  therapeutic use
Insulin Resistance
Matrix Metalloproteinases / physiology
Plasminogen / physiology
Plasminogen Activator Inhibitor 1 / physiology
Stroke / blood,  etiology,  prevention & control
Thromboembolism / blood,  etiology,  prevention & control
Tissue Plasminogen Activator / physiology
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Plasminogen Activator Inhibitor 1; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen; EC Plasminogen Activator; EC 3.4.24.-/Matrix Metalloproteinases

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