Document Detail

Fibrinolytic therapy of prosthetic mitral valve thrombosis during pregnancy: three case reports and review of the literature.
MedLine Citation:
PMID:  19825917     Owner:  NLM     Status:  MEDLINE    
The incidence of prosthetic valve thrombosis (PVT), which is a life-threatening complication, increased during pregnancy because of the hypercoagulable state. Despite adequate anticoagulation, the incidence of PVT has been estimated as 4% to 14% during pregnancy. Prosthetic valve thrombosis occurring during pregnancy requires urgent therapy including fibrinolytic therapy, valve replacement, and surgical thrombectomy due to high mortality. Although surgery has traditionally been the standard procedure for treatment of PVT, fibrinolytic therapy may be used as first-line therapy according to data from the recent reports. Data about the fibrinolytic therapy is scarce and controversial in the setting of pregnancies complicated with PVT. Herein, we share the outcomes of 3 pregnant women complicated with PVT and treated with recombinant tissue-type plasminogen activator.
Orhan Ozer; Vedat Davutoglu; Hatice E Soydinc; Fatma B Cebesoy; Ibrahim Sari; Murat Akcay
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-10-13
Journal Detail:
Title:  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis     Volume:  16     ISSN:  1938-2723     ISO Abbreviation:  Clin. Appl. Thromb. Hemost.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508125     Medline TA:  Clin Appl Thromb Hemost     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-13     Citation Subset:  IM    
Department of Cardiology, School of Medicine, Gaziantep University, Turkey.
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MeSH Terms
Coronary Thrombosis / drug therapy*,  ultrasonography
Fibrinolytic Agents / therapeutic use*
Heart Valve Diseases / drug therapy*,  ultrasonography
Heart Valve Prosthesis / adverse effects*
Mitral Valve / surgery*,  ultrasonography
Pregnancy Complications, Cardiovascular / blood,  surgery*,  ultrasonography
Thrombolytic Therapy / methods*
Young Adult
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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