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Fibrinolysis in pseudotumor cerebri.
MedLine Citation:
PMID:  17590719     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pseudotumor cerebri is a syndrome associated with diverse putative etiological factors that include chemicals such as vitamin A, tetracycline and estrogens or venous circulatory disturbances like sagittal or transverse sinus thrombosis. Diseases predisposing to thrombosis, such as polycythemia vera and essential thrombocythemia, were reported to cause sinus thrombosis and pseudotumor cerebri. This is a pilot study to investigate the possible role of hemostatic factors in the pathogenesis of pseudotumor cerebri. We studied nine patients with severe, recurrent, or refractory pseudotumor cerebri causing visual impairment and found abnormal euglobulin clot lysis time (prestress in all of them and post stress in seven). Digital subtraction angiography was suggestive of recanalized sinus thrombosis in only three patients. We conclude that abnormalities in the fibrinolytic system are present in a subset of patients with severe pseudotumor cerebri, which calls for further studies on venous circulatory pathogenesis of pseudotumor cerebri and the possible role of anticoagulants in such cases.
Authors:
M Z Al-Kawi; P S Chavis; G T Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  13     ISSN:  0256-4947     ISO Abbreviation:  Ann Saudi Med     Publication Date:  1993 Sep 
Date Detail:
Created Date:  2007-06-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  412-5     Citation Subset:  -    
Affiliation:
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, and Division of Neuro-Ophthalmology, King Khalid Eye Specialist Hospital, Riyadh, and Department of Pathology, Victoria General Hospital, Halifax, Canada.
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