Document Detail

Fibrinolysis in coronary artery surgery: detection by thromboelastography.
MedLine Citation:
PMID:  17709365     Owner:  NLM     Status:  MEDLINE    
Sixty-five patients scheduled for coronary surgery were randomized into three groups: A - conventional coronary artery bypass grafting, B - off-pump surgery, C - coronary artery bypass grafting with modified, rheoparin coated cardiopulmonary bypass with the avoidance of re-infusion of cardiotomy blood into the circuit. On the completion of peripheral bypass anastomoses, highly significant inter-group differences were found in the thromboelastographic parameter lysis of set time at 60 min of assessment (P=0.003) and at 150 min of assessment (P<0.001), the mean values of these parameters were significantly lower in group A as compared with both groups B and C, which were statistically indistinguishable. Lysis on set time on the completion of peripheral bypass anastomoses <50% was detected in 12 patients (52.2%) originating from group A. At the other sampling times (preoperatively, 15 min after sternotomy, at the end of the procedures, and 24 h later) thromboelastographic parameters were similar in all groups. In group A no significant correlations between lysis on set time, postoperative blood loss and D-dimer levels were found. Based on our results, thromboelastographic signs of fibrinolysis were clearly detectable during cardiopulmonary bypass in group A, but not at any time in groups B and C.
Tomas Vanek; Martin Jares; Jana Snircova; Marek Maly
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-08-20
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  6     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-27     Completed Date:  2007-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  700-4     Citation Subset:  IM    
Department of Cardiac Surgery, 3rd Faculty of Medicine, Charles University Prague and University Hospital Kralovske Vinohrady, Czech Republic.
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MeSH Terms
Anastomosis, Surgical
Biocompatible Materials
Blood Loss, Surgical / prevention & control
Cardiopulmonary Bypass / instrumentation*
Coronary Artery Bypass*
Coronary Artery Bypass, Off-Pump*
Equipment Design
Erythrocyte Transfusion
Fibrin Fibrinogen Degradation Products / metabolism
Myocardial Ischemia / blood,  surgery*
Prospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Biocompatible Materials; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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