Document Detail


Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse.
MedLine Citation:
PMID:  11891199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In humans, maternal fibrinogen (Fg) is required to support pregnancies by maintaining hemostatic balance and stabilizing uteroplacental attachment at the fibrinoid layer found at the fetal-maternal junction. To examine relationships between low Fg levels and early fetal loss, a genetic model of afibrinogenemia was developed. Pregnant mice homozygous for a deletion of the Fg-gamma chain, which results in a total Fg deficiency state (FG(-/-)), aborted the fetuses at the equivalent gestational stage seen in humans. Results obtained from timed matings of FG(-/-) mice showed that vaginal bleeding was initiated as early as embryonic day (E)6 to 7, a critical stage for maternal-fetal vascular development. The condition of afibrinogenemia retarded embryo-placental development, and consistently led to abortion and maternal death at E9.75. Lack of Fg did not alter the extent or distribution pattern of other putative factors of embryo-placental attachment, including laminin, fibronectin, and Factor XIII, indicating that the presence of fibrin(ogen) is required to confer sufficient stability at the placental-decidual interface. The results of these studies demonstrate that maternal Fg plays a critical role in maintenance of pregnancy in mice, both by supporting proper development of fetal-maternal vascular communication and stabilization of embryo implantation.
Authors:
Takayuki Iwaki; Mayra J Sandoval-Cooper; Melissa Paiva; Takao Kobayashi; Victoria A Ploplis; Francis J Castellino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pathology     Volume:  160     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-04-02     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1021-34     Citation Subset:  AIM; IM    
Affiliation:
W. M. Keck Center for Transgene Research, Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology*,  genetics,  metabolism
Afibrinogenemia / complications*,  genetics,  metabolism
Animals
Embryo Implantation* / genetics
Female
Fibrinogen / genetics,  metabolism
Maternal-Fetal Exchange* / genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Placenta / metabolism*,  pathology
Pregnancy
Pregnancy Complications, Hematologic / etiology*,  metabolism
Grant Support
ID/Acronym/Agency:
HL-13423/HL/NHLBI NIH HHS; HL63682/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
9001-32-5/Fibrinogen
Comments/Corrections

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