| Fibrinogen and silent atherosclerosis in subjects with cardiovascular risk factors. | |
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MedLine Citation:
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PMID: 7670937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrinogen may play an active role in the development and progression of atherosclerotic plaques. We assessed the association between fibrinogen levels and atherosclerotic plaques over three different arterial sites in an asymptomatic never-treated male population with increased cardiovascular risk. We included 652 men aged 40 to 60 years old with at least one of the following cardiovascular risk factors: cholesterol > 6.2 mmol/L and/or systolic blood pressure > or = 160 mm Hg and/or diastolic blood pressure > or = 95 mm Hg, and/or because they smoked. Carotid and femoral arteries and the abdominal aorta were assessed by using ultrasonographic methods for the presence of plaque, and subjects were categorized according to the presence (or absence) and extent (one versus two or three sites) of plaque. Plasma fibrinogen was measured according to the thrombin-time method of Clauss. While the presence of atherosclerosis was significantly related to age, current smoking, systolic pressure, LDL cholesterol, and fibrinogen levels, the extent of atherosclerosis was related to age and triglyceride and fibrinogen levels. Multiple regression analysis indicated independent associations between fibrinogen and the presence and extent of atherosclerosis. Plaque prevalence was significantly more pronounced with increasing tertile of fibrinogen levels. The odds ratio of the upper to lower fibrinogen tertiles for the presence of plaque was 1.6 (95% confidence interval, 1.4 to 1.8) and 1.4 (95% confidence interval, 1.2 to 1.7) for its extent. Adjustment for other risk factors slightly reduced the association between fibrinogen and atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J Levenson; P Giral; M Razavian; J Gariepy; A Simon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 15 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-10-13 Completed Date: 1995-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1263-8 Citation Subset: IM |
Affiliation:
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Centre de Médecine Préventive Cardiovasculaire, Broussais Hospital, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aorta / ultrasonography Arteriosclerosis / etiology* Blood Pressure Cardiovascular Diseases / etiology* Carotid Arteries / ultrasonography Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Femoral Artery / ultrasonography Fibrinogen / metabolism* Humans Male Middle Aged Regression Analysis Risk Factors Smoking / adverse effects Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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