| Fibrinogen polymorphisms and atherothrombotic disease. | |
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MedLine Citation:
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PMID: 11460514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Common polymorphisms of the fibrinogen gene cluster are associated with circulating fibrinogen level and with susceptibility to and/or severity of atherothrombotic disease. The frequencies of the polymorphisms vary among different ethnic groups but there is strong linkage disequilibrium at the beta-fibrinogen gene locus so that, in caucasian populations, there are only four common beta-fibrinogen haplotypes. One of these haplotypes, defined by the beta-fibrinogen -455A allele, is associated with elevated fibrinogen level and increased risk of atherothrombotic disease. The molecular mechanism of these associations is currently under investigation. |
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Authors:
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F R Green |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 936 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-07-19 Completed Date: 2001-08-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 549-59 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, United Kingdom. fionag@well.ox.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteriosclerosis
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genetics* Fibrinogen / genetics* Haplotypes Humans Linkage Disequilibrium Polymorphism, Genetic* Thrombosis / genetics* |
| Chemical | |
Reg. No./Substance:
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9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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