Document Detail

Fibrinogen polymorphisms are not associated with the risk of myocardial infarction.
MedLine Citation:
PMID:  11054085     Owner:  NLM     Status:  MEDLINE    
In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms in the alpha- and beta-fibrinogen genes among 560 patients with a myocardial infarction and 646 control subjects. Secondly, we studied the relationships between these polymorphisms and fibrinogen activity and antigen levels. The TaqI, HaeIII and BclI polymorphisms in the fibrinogen gene were not associated with myocardial infarction. As we found an association of the rare B2 allele with fibrinogen levels and a similar, but weak, effect for the rare H2 allele, we conclude that a genetic propensity to high fibrinogen levels does not affect the risk of myocardial infarction. This is evidence against a causal role for fibrinogen levels in the aetiology of myocardial infarction.
C J Doggen; R M Bertina; V M Cats; F R Rosendaal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  110     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-11-09     Completed Date:  2000-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  935-8     Citation Subset:  IM    
Department of Clinical Epidemiology, Leiden University Medical Centre, The Netherlands.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Fibrinogen / genetics*
Middle Aged
Myocardial Infarction / etiology*,  genetics
Polymorphism, Genetic*
Reg. No./Substance:

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