| Fibrinogen metabolism in the lungs. | |
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MedLine Citation:
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PMID: 15690323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the role of the pulmonary vessel endothelium in the metabolism of fibrinogen (FBG), by measuring the FBG, D-dimer, and fibrin(ogen) degradation product levels in the blood from pulmonary and radial arteries from 99 patients undergoing aortocoronary bypass. For comparison, protein C, protein S, and factor VII, were also measured. The results showed, with respect to the pulmonary arterial blood levels, significantly lower FBG levels (3.72 +/- 0.83 vs 3.66 +/- 0.81 g/L; P < .001) and higher fibrin(ogen) degradation product levels (7.36 +/- 1.53 vs 8.15 +/- 1.59 mg/L; P < .000 01) in the radial arterial blood. No difference was found for d -dimer, protein C, protein S, and factor VII. The study demonstrated that the pulmonary capillary endothelium contributes to the FBG catabolism for about a 0.02 fractional rate and support the view of an endothelial FBG catabolic pathway as the main catabolic pathway, owing to the fact that the pulmonary endothelial surface is about a 0.1 fraction of the peripheral vessel endothelial surface. |
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Authors:
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Giuseppe Aliberti; Isabella Pulignano; Angelo Schiappoli; Fabrizio Ceci; Luigi Tritapepe; Claudio Di Giovanni; Massimo Trappolini; Maria Proietta |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 54 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-03 Completed Date: 2005-03-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 271-4 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Cliniche, Università di Roma La Sapienza, Italy. giuseppe.aliberti@uniroma.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endothelium, Vascular
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drug effects,
metabolism Factor VII / metabolism Female Fibrinogen / metabolism* Humans Lung / metabolism* Male Middle Aged Protein C / metabolism Protein S / metabolism Pulmonary Artery / metabolism Radial Artery / metabolism Stress, Physiological / metabolism Thrombin / biosynthesis Thromboplastin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Protein C; 0/Protein S; 9001-25-6/Factor VII; 9001-32-5/Fibrinogen; 9035-58-9/Thromboplastin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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