Document Detail

Fibrinogen, factor VIII related antigen, antithrombin III and alpha 2-antiplasmin in peripheral arterial disease.
MedLine Citation:
PMID:  6442467     Owner:  NLM     Status:  MEDLINE    
In 306 subjects, 217 without and 89 with peripheral arterial disease (PAD), VIIIR:Ag and alpha 2-antiplasmin are significantly higher in PAD (p less than 0.01). In the PAD negative group the ratio alpha 2-antiplasmin/antithrombin III activity is significantly higher 1.11 +/- 0.3 in the patients with an abnormal exercise ECG typical of coronary disease than in normal subjects 1.02 +/- 0.2 (p less than 0.05). In the PAD positive group antithrombin III concentration is higher in patients with a normal exercise ECG than in patients with abnormal exercise ECG (p less than 0.05). The same is true for alpha 2-antiplasmin but not for the antithrombin III activity. Fibrinogen and VIIIR:Ag are higher in patients with a previous myocardial infarction, however, the age is also significantly different as compared to the group without previous myocardial infarction. Disturbance of the cerebral arterial circulation is characterized by an elevation of VIIR:Ag and of alpha 2-antiplasmin as compared to the values obtained in patients without this complication. There is a general tendency towards higher alpha 2-antiplasmin values with the extension of the arterial disease.
M Christe; A Delley; G A Marbet; L Biland; F Duckert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  52     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  240-2     Citation Subset:  IM    
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MeSH Terms
Antigens / analysis
Antithrombin III / metabolism
Arterial Occlusive Diseases / blood*
Cerebral Arterial Diseases / blood
Factor VIII / analysis,  immunology
Fibrinogen / metabolism
Myocardial Infarction / blood
alpha-2-Antiplasmin / metabolism
von Willebrand Factor
Reg. No./Substance:
0/Antigens; 0/alpha-2-Antiplasmin; 0/von Willebrand Factor; 9000-94-6/Antithrombin III; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen

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