| Fibrinogen depletion and control of permeability in oleic acid lung injury. | |
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MedLine Citation:
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PMID: 2001075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if the biphasic pulmonary clearance of aerosolized 99mTc diethylene penta acetate (99mTc-DTPA) observed in oleic acid lung injury represents acute epithelial damage followed by sealing as a result of intra-alveolar fibrin deposition, we examined the effect of fibrinogen depletion. 99mTc-DTPA clearance was assessed in three groups of rabbits: Group 1, normal fibrinogen + oleic acid injury; Group 2, fibrinogen-depleted + oleic acid injury; Group 3, fibrinogen-depleted with no oleic acid injury. In Group 3 animals with no lung injury, the 99mTc-DTPA clearance rate, expressed as k, the percent decrease in thoracic radioactivity, was similar to that previously reported for healthy rabbits (k = 1.16 +/- 0.57%/min, mean +/- SD). Oleic acid administration to Groups 1 and 2 resulted in significantly faster clearance rates, with identical biphasic curves in all animals, irrespective of fibrinogen status. There were no significant differences between either the initial fast phase (k, Group 1 = 5.26 +/- 1.83%/min, Group 2 = 5.70 +/- 1.77%/min) or the subsequent slow phase (k, Group 1 = 1.67 +/- 0.63%/min, Group 2 = 1.57 +/- 0.55%/min, p greater than 0.05). On histologic examination, Groups 1 and 2 showed greater cellular interstitial infiltrate, alveolar edema, and hemorrhage than did Group 3. Fibrinogen depletion plus oleic acid injury resulted in greater alveolar cellular exudate, edema, and hemorrhage than did either oleic acid or fibrinogen depletion alone. We conclude that fibrinogen is not necessary to produce biphasic 99mTc-DTPA clearance in oleic acid lung injury. |
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Authors:
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A L Jefferies; D Fung; J B Mullen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American review of respiratory disease Volume: 143 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-10 Completed Date: 1991-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 618-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillary Permeability* Fibrinogen / analysis, drug effects, physiology* Lung / radionuclide imaging Oleic Acid Oleic Acids Pulmonary Edema / blood, chemically induced, physiopathology*, radionuclide imaging Rabbits Technetium Tc 99m Pentetate / diagnostic use Viper Venoms / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Oleic Acids; 0/Viper Venoms; 112-80-1/Oleic Acid; 65454-61-7/Technetium Tc 99m Pentetate; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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