| Fibrinogen-coated chylomicrons in gastrointestinal lymph: a new rationale regarding the arterial deposition of postprandial lipids. | |
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MedLine Citation:
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PMID: 12445516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recent discovery that fibrinogen binds to chylomicrons in gastrointestinal lymph has prompted a new rationale regarding the arterial deposition of postprandial lipids, i.e., dietary fat. According to this new rationale, fibrinogen bound to chylomicrons in the gastrointestinal lymph renders those lipid particles and/or their remnants an adhesive potential, even before the particles reach the arterial system. It is proposed that such an adhesive potential, if realized in the vicinity of the arterial wall, can contribute to the nucleation and growth of atherosclerotic plaques, especially during and immediately following a fat-rich meal. Arguments in support of this proposal are made based on the proximity of the lymph outflow tract to the arteries most susceptible to atherosclerosis, and on the tissue distributions and activities of heparin, diamine oxidase, and lipoprotein lipase. This new rationale reconciles existing theories on atherosclerosis, and it also suggests novel means by which to prevent/treat the disease. |
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Authors:
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Gregory S Retzinger |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 59 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-06-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 718-26 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science Ltd. |
Affiliation:
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Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529, USA. retsings@email.uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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physiology* Chylomicrons / metabolism* Dietary Fats* Digestive System Physiological Phenomena* Fibrinogen / metabolism* Humans Lipid Metabolism* Lymphatic System / physiology* Models, Biological Postprandial Period |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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