Document Detail

Fibrinogen Kawaguchi: an abnormal fibrinogen characterized by defective release of fibrinopeptide A.
MedLine Citation:
PMID:  3992527     Owner:  NLM     Status:  MEDLINE    
A congenital dysfibrinogenemia was found in a 32-year-old asymptomatic female and her immediate family. The propositus, apparently a heterozygote for the abnormality, characteristically showed defective release of fibrinopeptide A from half of her fibrinogen molecules. No fibrinopeptide A was cleaved off from the isolated abnormal molecule by thrombin or snake venoms (Reptilase and Ancrod) as evidenced by radioimmunoassay, high performance liquid chromatography and determination of the NH2-terminal amino acids. The abnormal fibrinogen formed a solid gel solely by the release of fibrinopeptide B upon incubation with thrombin. We provisionally designate this abnormal fibrinogen as "Fibrinogen Kawaguchi", although possible identity with other abnormal fibrinogens is not excluded.
M Matsuda; E Saeki; A Kasamatsu; C Nakamikawa; S Manabe; Y Samejima
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis research     Volume:  37     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-06-10     Completed Date:  1985-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  379-90     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Blood Coagulation Disorders / blood,  genetics*
Fibrin / metabolism
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / metabolism*
Fibrinogens, Abnormal*
Fibrinopeptide A / metabolism
Thrombin Time
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Fibrinogens, Abnormal; 0/fibrinogen Kawaguchi; 25422-31-5/Fibrinopeptide A; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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