Document Detail

Fibrin sealant provides superior hemostasis for sternotomy compared with bone wax.
MedLine Citation:
PMID:  22269729     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: The purpose of this study was to evaluate the hemostatic efficacy and feasibility of direct injection of fibrin sealant into the sternal marrow cavity in senior patients undergoing on-pump coronary artery bypass grafting (CABG).
DESCRIPTION: A total of 82 senior patients undergoing on-pump CABG were randomized to the bone wax group (n = 40) or the fibrin sealant group (n = 42) for the period July 2010 to January 2011.
EVALUATION: The fibrin sealant-treated group had less chest drainage in the first 24 hours (186.67 ± 49.53 versus 333.75 ± 60.49 mL), less total chest drainage (326.19 ± 67.24 versus 516 ± 88.46 mL), less packed red blood cell (PRBC) administration (3.6 ± 1.25 versus 7.4 ± 2.13 U), less fresh frozen plasma (FFP) administration (5.52 ± 1.64 versus 8.95 ± 1.77 U), shorter intubation time (40.36 ± 8.62 versus 46.25 ± 10.46 hours), and shorter hospital stay (10.45 ± 1.17 versus 11.03 ± 1.37 days) compared with the bone wax group. No significant difference in the incidence of postoperative complications was found.
CONCLUSIONS: Direct injection of fibrin sealant into the sternal marrow cavity significantly reduces the amount of postoperative blood loss and offers an attractive new treatment alternative for senior patients undergoing on-pump CABG.
Lei Yu; Tianxiang Gu; Laichun Song; Enyi Shi; Qin Fang; Chun Wang; Jin Zhao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  93     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  641-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang, PR China.
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