| Fibrin sealant provides superior hemostasis for sternotomy compared with bone wax. | |
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MedLine Citation:
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PMID: 22269729 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to evaluate the hemostatic efficacy and feasibility of direct injection of fibrin sealant into the sternal marrow cavity in senior patients undergoing on-pump coronary artery bypass grafting (CABG). DESCRIPTION: A total of 82 senior patients undergoing on-pump CABG were randomized to the bone wax group (n = 40) or the fibrin sealant group (n = 42) for the period July 2010 to January 2011. EVALUATION: The fibrin sealant-treated group had less chest drainage in the first 24 hours (186.67 ± 49.53 versus 333.75 ± 60.49 mL), less total chest drainage (326.19 ± 67.24 versus 516 ± 88.46 mL), less packed red blood cell (PRBC) administration (3.6 ± 1.25 versus 7.4 ± 2.13 U), less fresh frozen plasma (FFP) administration (5.52 ± 1.64 versus 8.95 ± 1.77 U), shorter intubation time (40.36 ± 8.62 versus 46.25 ± 10.46 hours), and shorter hospital stay (10.45 ± 1.17 versus 11.03 ± 1.37 days) compared with the bone wax group. No significant difference in the incidence of postoperative complications was found. CONCLUSIONS: Direct injection of fibrin sealant into the sternal marrow cavity significantly reduces the amount of postoperative blood loss and offers an attractive new treatment alternative for senior patients undergoing on-pump CABG. |
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Authors:
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Lei Yu; Tianxiang Gu; Laichun Song; Enyi Shi; Qin Fang; Chun Wang; Jin Zhao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 93 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 641-4 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiac Surgery, the First Affiliated Hospital of China Medical University, Shenyang, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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