| Fibrin ring granulomas and allopurinol. | |
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MedLine Citation:
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PMID: 2925064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that allopurinol-associated granulomatous hepatitis may present itself with fibrin-ring granulomas, we requested details of such cases, as reported to the World Health Organization, from 13 national adverse reaction monitoring centers, and as reported in the literature. Details and histology of 6 cases were obtained and reviewed. All consisted of acute hypersensitivity signs with fever, rash, arthralgia, or eosinophilia as hallmarks, starting within 6 wk of commencing treatment with allopurinol. In all cases there were either epithelioid granulomas or granulomalike lesions, but none of these contained fibrin rings. It is concluded that, if fibrin-ring granulomas are a manifestation of allopurinol-induced granulomatous hepatitis, this feature is probably uncommon. |
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Authors:
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B H Stricker; A P Blok; G Babany; J P Benhamou |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 96 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1989-04-27 Completed Date: 1989-04-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1199-203 Citation Subset: AIM; IM |
Affiliation:
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Netherlands Centre for Monitoring of Adverse Reactions to Drugs, Rijswijk, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Allopurinol / adverse effects* Drug-Induced Liver Injury / etiology, pathology* Female Fibrin / analysis Granuloma / chemically induced*, pathology Humans Male |
| Chemical | |
Reg. No./Substance:
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315-30-0/Allopurinol; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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