| Fibrin: mediator of in vivo and in vitro injury and inflammation. | |
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MedLine Citation:
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PMID: 3874755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the role that fibrin deposition and fibrin-associated factors (FAF) play in acute anterior segment inflammatory responses in the rabbit eye. It was demonstrated by immunofluorescence that fibrin represented a major component of the exudative meshwork deposited within the anterior chamber and on leukocyte surfaces therein. Using our in vivo model of endocular inflammation we next demonstrated that fibrin and fibrinogen-derived peptides, but not thrombin, induced inflammatory responses characterized by both leukocyte influx and endothelial cell injury. Fibrin formation within the anterior chamber induced a leukocyte influx consisting primarily of PMN's. Fibrinogen-derived peptides induced primarily a monocyte influx. This dichotomy suggests that multiple inflammatory mediators are elaborated or released during endocular fibrinogenesis and fibrinolysis. To investigate direct effects of fibrin deposition on the corneal endothelial cells (CEC) an in vitro "corneal cup" organ culture model was next developed. Studies comparing various types of mediators demonstrated that only fibrin- derived preparations directly induced CEC injury. Fibrin deposition may thus play multiple roles in endocular inflammation, including the modulation of leukocyte influx, and the direct mediation of corneal endothelial cell injury. |
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Authors:
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F N Rowland; M J Donovan; C Gillies; J O'Rourke; D L Kreutzer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Current eye research Volume: 4 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-09-25 Completed Date: 1985-09-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 537-53 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anterior Eye Segment* Cornea / drug effects, pathology, ultrastructure Endophthalmitis / physiopathology Endothelium / drug effects, pathology, ultrastructure Fibrin / physiology* Fibrin Fibrinogen Degradation Products / pharmacology, physiology Fibrinogen / pharmacology Microscopy, Electron Rats |
| Grant Support | |
ID/Acronym/Agency:
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EY00123/EY/NEI NIH HHS; EY04131/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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