Document Detail

Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial.
MedLine Citation:
PMID:  19019930     Owner:  NLM     Status:  MEDLINE    
AIMS: To compare the degree of conjunctival autograft inflammation, subconjunctival haemorrhage (SCH) and graft stability following the use of sutures or fibrin glue (FG) during pterygium surgery. METHODS: Prospective, observer masked, clinical trial. 40 eyes of 40 patients undergoing primary pterygium surgery with conjunctival autograft were allocated into two groups. Group 1 (n = 20) had FG (Tisseel) for attaching the conjunctival autograft, whereas group 2 (n = 20) had sutures. Standardised digital slit-lamp photographs were taken at 1 week, 1 month and 3 months postoperatively. Sutures were masked using commercially available photo-editing software. Two masked observers objectively graded the digital photographs for degree of inflammation, SCH and graft stability. RESULTS: 34 of the 40 patients completed the study. When using FG, the degree of inflammation was significantly less than with sutures at 1 month (p = 0.019) and 3 months (p = 0.001) postoperatively. No significant difference was found for inflammation at 1 week postoperatively (p = 0.518). Conjunctival grafts secured with FG were as stable as those secured with sutures (p = 0.258, p = 0.076 and p = 0.624, at 1 week, 1 month and 3 months, respectively). No significant difference was found in degree of postoperative SCH between the groups (p = 0.417, p = 1 and p = 1, at 1 week, 1 month and 3 months, respectively). CONCLUSION: This is the first prospective clinical trial confirming that conjunctival grafts secured with FG during pterygium surgery not only are as stable as those secured with sutures, but also produce significantly less inflammation.
S Srinivasan; M Dollin; P McAllum; Y Berger; D S Rootman; A R Slomovic
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article     Date:  2008-11-19
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  93     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
Department of Ophthalmology, Toronto Western Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Conjunctiva / transplantation*
Conjunctivitis / etiology
Eye Hemorrhage / etiology
Fibrin Tissue Adhesive / adverse effects,  therapeutic use*
Graft Survival
Middle Aged
Postoperative Complications
Prospective Studies
Pterygium / surgery*
Single-Blind Method
Sutures* / adverse effects
Tissue Adhesives / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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