Document Detail

Fibrin generated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis.
MedLine Citation:
PMID:  12509608     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Fibrin deposits adhered to the synovial surface are typical of rheumatoid joints. Since fibrin appears to have a role in arthritis perpetuation our aim was to investigate how these deposits are formed and the consequences of their adhesion to the tissue. METHODS: The appearance of fibrin aggregates either free in the synovial fluid or attached to the membrane was studied in rabbits with antigen-induced arthritis by histological techniques at different time points from challenge. In the fixed synovial membranes areas of fibrin-bound synovium were evaluated by qualitative variables to obtain a sequential profile of morphological changes. RESULTS: Fibrin aggregates appeared from the initial stages of the disease in the synovial effusion. Later on, they were localized on the synovial surface and progressive changes were noted at the fibrin-tissue interface, ending with the invasion of the aggregates by synovial cells and their incorporation into the tissue. CONCLUSION: Fibrin aggregates generated inside the joint cavity may constitute a source of activation and acquisition of invasiveness of the synovial fibroblasts, a process to explore within the perpetuating mechanisms of rheumatoid arthritis.
O Sánchez-Pernaute; M J López-Armada; E Calvo; I Díez-Ortego; R Largo; J Egido; G Herrero-Beaumont
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  42     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-01     Completed Date:  2003-02-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  AIM; IM    
Inflammation Research Unit, Division of Rheumatology, Fundación Jiménez Díaz, Universidad Autónoma, Av. Reyes Católicos 2, 28040 Madrid, Spain.
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MeSH Terms
Arthritis, Rheumatoid / metabolism*,  pathology
Fibrin / analysis*
Fibrinogen / analysis
Fibroblasts / pathology
Fibronectins / analysis
Models, Animal
Synovial Fluid / metabolism*
Synovial Membrane / metabolism*,  pathology
Synovitis / metabolism*
Time Factors
Tissue Adhesions
Reg. No./Substance:
0/Fibronectins; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; 9006-59-1/Ovalbumin

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