Document Detail

Fibrin-fibrinogen degradation products in cerebrospinal fluid of patients admitted to a psychiatric unit.
MedLine Citation:
PMID:  4829529     Owner:  NLM     Status:  MEDLINE    
Paired cerebrospinal fluid (CSF) and serum samples collected from 81 of 241 patients admitted to a district psychiatric hospital during a six month period were assayed for fibrin/fibrinogen degradation products (FDP) using a haemagglutination inhibition technique. FDP were found in all serum samples. Fifteen patients (18·5%) had FDP in the CSF (range 0·7-3·75 μg/ml.) and of these 13 (87%) had associated CSF protein abnormalities and 9 (60%) were hypertensive. Mean serum FDP values were the same (4·4 μg/ml.) in patients with and without FDP in the CSF. Three patients had raised serum FDP concentrations but no FDP in the CSF. The evidence suggests that the presence of FDP in CSF indicates recent central nervous system damage. In this series the most common cause was vascular disease.
R Hunter; T Thomson; C M Reynolds; P M Pitcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  37     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1974 Mar 
Date Detail:
Created Date:  1974-07-18     Completed Date:  1974-07-18     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Brain Diseases / cerebrospinal fluid*
Brain Neoplasms / cerebrospinal fluid
Cerebrospinal Fluid Proteins / analysis
Cerebrovascular Disorders / cerebrospinal fluid
Encephalitis / cerebrospinal fluid
Fibrin / analysis,  cerebrospinal fluid*
Fibrinogen / analysis,  cerebrospinal fluid*
Hemagglutination Inhibition Tests
Intracranial Arteriosclerosis / cerebrospinal fluid
Middle Aged
Reg. No./Substance:
0/Cerebrospinal Fluid Proteins; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen

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