| Fibrin configuration on glass led to decrease of neutrophil adherence in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 3388313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a previously developed in vitro assay of glass adherence of neutrophils following blood clotting, we compared the results of new patients with systemic lupus erythematosus (SLE), juvenile rheumatoid arthritis (JRA) and those of normal controls. In acute phase of the disease, all 33 patients (100%) of SLE, 2 of 35 patients (5.7%) with JRA had a significantly low neutrophil adherence to glass surface (less than 25% of the normal values). During 2 years follow-up in 18 patients with SLE from the onset of the disease, we consistently observed the low cell adherence during the relapses of the disease in all the patients. When remains of glass surfaces were examined under scanning electron microscope (SEM), we found a notable morphologic difference of fibrin configuration between the specimens of active SLE and normal controls. We conclude that the varied results of neutrophil adherence on glass may reflect the forming of different fibrin configuration induced by the in vitro contact system of coagulation. The findings may explain the increased thrombotic complications reported in patients with active SLE. |
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Authors:
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S W Huang; E J Ruley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis research Volume: 49 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-08-08 Completed Date: 1988-08-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 613-21 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Maryland, Baltimore 21201. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cell Adhesion Complement C3 / analysis Female Fibrin / physiology* Glass Humans Lupus Erythematosus, Systemic / physiopathology* Male Microscopy, Electron, Scanning Neutrophils / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 9001-31-4/Fibrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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