Document Detail

Fibrin configuration on glass led to decrease of neutrophil adherence in systemic lupus erythematosus.
MedLine Citation:
PMID:  3388313     Owner:  NLM     Status:  MEDLINE    
Using a previously developed in vitro assay of glass adherence of neutrophils following blood clotting, we compared the results of new patients with systemic lupus erythematosus (SLE), juvenile rheumatoid arthritis (JRA) and those of normal controls. In acute phase of the disease, all 33 patients (100%) of SLE, 2 of 35 patients (5.7%) with JRA had a significantly low neutrophil adherence to glass surface (less than 25% of the normal values). During 2 years follow-up in 18 patients with SLE from the onset of the disease, we consistently observed the low cell adherence during the relapses of the disease in all the patients. When remains of glass surfaces were examined under scanning electron microscope (SEM), we found a notable morphologic difference of fibrin configuration between the specimens of active SLE and normal controls. We conclude that the varied results of neutrophil adherence on glass may reflect the forming of different fibrin configuration induced by the in vitro contact system of coagulation. The findings may explain the increased thrombotic complications reported in patients with active SLE.
S W Huang; E J Ruley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  49     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-08-08     Completed Date:  1988-08-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-21     Citation Subset:  IM    
Department of Pediatrics, University of Maryland, Baltimore 21201.
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MeSH Terms
Cell Adhesion
Complement C3 / analysis
Fibrin / physiology*
Lupus Erythematosus, Systemic / physiopathology*
Microscopy, Electron, Scanning
Neutrophils / physiology*
Reg. No./Substance:
0/Complement C3; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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