| Fibrin d-dimer concentration, deep vein thrombosis symptom duration, and venous thrombus volume. | |
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MedLine Citation:
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PMID: 20834027 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: To determine the relationship between fibrin D-dimer levels, symptom duration, and thrombus volume, consecutive patients with incident deep venous thrombosis (DVT) were evaluated. Methods: In a cross-sectional study design, patient symptom onset was determined by careful patient questioning. Venous thrombosis was confirmed by compression duplex ultrasonography. Thrombus volume was estimated based on patient's femur length using a forensic anthropology method. Fibrin D-dimer was measured by latex immunoassay. Results: 72 consecutive patients with confirmed leg DVT agreed to participate. The median symptom duration at the time of diagnosis was 10 days. The median D-dimer concentration was 1050 ng/dL. The median thrombus volume was 12.92 cm(3). D-Dimer levels correlated with estimated thrombus volume (P < .0006 CI 0.12-0.41; R(2) (adjusted) = .15) but not symptom duration, patient's age, or gender. Conclusions: Despite varying symptom duration prior to diagnosis, fibrin D-dimer remains a sensitive measure of venous thrombosis and correlates with thrombus volume. |
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Authors:
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Andrew K Kurklinsky; Henna Kalsi; Waldemar E Wysokinski; Karen F Mauck; Anjali Bhagra; Rachel D Havyer; Carrie A Thompson; Sharonne N Hayes; Robert D McBane |
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Publication Detail:
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Type: Journal Article Date: 2010-09-11 |
Journal Detail:
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Title: Angiology Volume: 62 ISSN: 1940-1574 ISO Abbreviation: Angiology Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 253-6 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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