| Fibrillins in Human Adult Ovary and Polycystic Ovary Syndrome: Is Fibrillin-3 Affected in PCOS? | |
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MedLine Citation:
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PMID: 20644211 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Polycystic ovary syndrome (PCOS) is a common endocrinopathy in reproductive aged women. Although genetic linkage analyses have demonstrated a susceptibility locus for PCOS mapping to the fibrillin-3 gene, the presence of fibrillin proteins in normal and polycystic ovaries has not been characterized. This study compared and contrasted fibrillin-1, -2, and -3 localization in normal and polycystic ovaries. Immunohistochemical stainings of ovaries from 21 controls and 9 patients with PCOS were performed. Fibrillin-1 was ubiquitous in ovarian connective tissue. Fibrillin-2 localized around antral follicles and in areas of folliculolysis. Fibrillin-3 was present in a restricted distribution within the specialized perifollicular stroma of follicles in morphologic transition from primordial to primary type (transitional follicles - TF). Fibrillin-1 and -2 stainings of PCOS ovaries were similar to the controls. However, in eight of the 9 PCOS ovaries, there was a decrease in the number of TF associated with fibrillin-3, including no staining in five PCOS samples; decreased fibrillin-3 associated TF/mm(2) was confirmed by quantitative analysis. Our findings support a role for fibrillin-3 in the pathogenesis of PCOS and suggest fibrillin-3 may function in primordial to primary follicle transition. We propose that loss of fibrillin-3 during folliculogenesis may be an important factor in PCOS pathogenesis. |
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Authors:
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C Diana Jordan; Sandra D Bohling; Noe L Charbonneau; Lynn Y Sakai |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-7-19 |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: - ISSN: 1551-5044 ISO Abbreviation: - Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pathology, University of Washington Medical Center, Seattle, Washington (CDJ,SDB); Shriners Hospital for Children, Portland, Oregon (NLC,LYS); and Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon (LYS). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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